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Prior to joining DMU Dr Safo worked at the University of Birmingham as an Experimental Officer in Metabolomics at Phenome Centre Birmingham, working on the H2020 PrecisionTox º£½ÇÉçÇø and other metabolomics projects in toxicology and cancer research. Dr Laudina Safo graduated from the University of Leicester in 2013 with M.Chem Pharmaceutical Chemistry with a year in industry. She did her research with the Chemical Biology team headed by Dr Andrew Jamieson looking at synthesising peptidomimetic of the beta-amyloid protein as a potential cure for Alzheimer's disease. During her time at the University of Leicester, she was awarded a studentship by the Royal Society of Chemistry (RSC) to undertake a summer internship in Analytical Chemistry working with Professor Andrew Ellis and his team to investigate the use of proton transfer reaction mass spectrometry (PTR-MS) in medical diagnostics through breath analysis. She developed a keen interest for Analytical Chemistry after this summer project and then went on to º£½ÇÉçÇø a PhD in Analytical Bioscience at the University of Nottingham, Centre for Analytical Bioscience (CAB) supervised by Professor David Barrett (funded by BBSRC). During her PhD, she developed and validated LC-MS/MS method for absolute quantification of intracellular metabolic changes in Clostridium autoethanogenum using liquid chromatography isotope dilution mass spectrometry (LC-IDMS). Her research focused on the use of mass spectrometry-based methods to optimise the production of native and non-native compounds present in the metabolic pathways of microorganisms to help reduce the overall global dependence on non-renewable fuel and energy resources. She obtained her PhD in 2018 from the University of Nottingham, School of Pharmacy and went on to work with the CAB group as a Research technician-Mass Spectrometry on the Beacon of Excellence- Green Chemicals project until July 2021. She continued her role in CAB as a Research Officer from July 2021. Over the years, she has developed LC-MS/MS methods for absolute quantification of over 100 metabolites present in different biological matrices. She has also developed LC-MS method for untargeted metabolomics studies with applications in disease biomarker discovery and clinical studies. Her expertise includes LC-MS(/MS) method development, untargeted metabolomics, targeted metabolomics, quantitative mass spectrometry, Isotope labelling/tracing in microorganisms and biomarker discovery.

Leicester Institute of Pharmaceutical Innovation for Integrated Care (LIPIIC)

1. Joshua P. Thompson, Omar Cristobal-Carballo, Tianhai Yan, Katie Lawther, Nicholas J. Dimonaco, Wayne E. Zeller, Zhenbin Zhang, Sharon Huws, Laudina Safo, Andrew D. Southam, Christian Ludwig, Gavin R. Lloyd, Sokratis Stergiadis & Katerina Theodorido. (2025), Unlocking the potential of willow condensed tannins: effects on rumen fermentation, microbiome, and metabolome for sustainable ruminant nutrition. Animal Microbiome, 7(81)
2. Alison Whitby, Pardeep Pabla, Bhoomi Shastri, Laudina Amugi, Álvaro Del Río-Álvarez, Dong-Hyun Kim, Laura Royo, Carolina Armengol, Madhumita Dandapani.(2023), Characterisation of Aberrant Metabolic Pathways in Hepatoblastoma Using Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS), 15(21) :5182
3. Alison Woodward, Laudina Amugi, Kishan Patel, Charlotte Kilpatrick, Dong-hyun Kim, Madhumita Dandapani. (2022), EPEN-21. Developing a sensitive method for detection of minimal residual disease in ependymoma using metabolomic analysis of cerebrospinal fluid. Neuro Oncol. 24(Suppl 1)
4. Laudina Safo, Salah Abdelrazig, Alexander Grosse-Honebrink, Thomas Millat, Anne M Henstra, Rupert Norman, Neil R Thomas, Klaus Winzer, Nigel P Minton, Dong-Hyun Kim, David A Barrett. (2021), Quantitative Bioreactor Monitoring of Intracellular Bacterial Metabolites in Clostridium autoethanogenum Using Liquid Chromatography-Isotope Dilution Mass Spectrometry. ACS Omega, 6(21): 13518–13526
5. Vaud, Sophie & Pearcy, Nicole & Hanževački, Marko & Hagen, Alexander & Abdelrazig, Salah & Safo, Laudina & Ehsaan, Muhammad & Jonczyk, Magdalena & Millat, Thomas & Craig, Sean & Spence, Edward & Fothergill, James & Bommareddy, Rajesh & Colin, Pierre-Yves & Twycross, Jamie & Dalby, Paul & Minton, Nigel & Jäger, Christof & Kim, Dong-Hyun & Bryan, Samantha. (2021). Engineering improved ethylene production: Leveraging systems Biology and adaptive laboratory evolution. Metabolic Engineering. 67. 10.1016/j.ymben.2021.07.001.
6. Lina Dahabiyeh; Nouf Mahmoud; Mohammad Al-Natour; Laudina Safo; Dong-Hyun Kim; Enam Khalil; Rana Abu-Dahab. 2021. "Phospholipid-Gold Nanorods Induce Energy Crisis in MCF-7 Cells: Cytotoxicity Evaluation Using LC-MS-Based Metabolomics Approach." Biomolecules 11, no. 3: 364.
7. Salah Abdelrazig; Laudina Safo; Graham A. Rance; Michael W. Fay; Eirini Theodosiou; Paul D. Topham; Dong-Hyun Kim; Alfred Fernández-Castané. 2020. "Metabolic characterisation of Magnetospirillum gryphiswaldense MSR-1 using LC-MS-based metabolite profiling." RSC Advances 10, no. 54: 32548-32560.
8. Sarah Schatschneider; Salah Abdelrazig; Laudina Safo; Anne Meint Henstra; Thomas Millat; Dong-Hyun Kim; Klaus Winzer; Nigel Peter Minton; David A. Barrett. 2018. "Quantitative Isotope-Dilution High-Resolution-Mass-Spectrometry Analysis of Multiple Intracellular Metabolites in Clostridium autoethanogenum with Uniformly 13C-Labeled Standards Derived from Spirulina." Analytical Chemistry 90, no. 7: 4470-4477.

• LC-MS metabolomics and lipidomics
• Quantitative Mass Spectrometry
• Biomarker discovery

Analytical Chemistry

• PhD Pharmacy (Analytical Bioscience)
• M,Chem Pharmaceutical Chemistry with a year in industry

MSc Bioinformatic and Bioanalysis (PHAR5312) , Analytical Forensic Science (FSCI2201), Professional Portfolio (PHCO1401 & FSCI2205)

• British Mass Spectrometry Society
• American Mass Spectrometry Society

• Jasira Patel
• Zuzanna Kula
• Manavi Manarangi Perera Podimarakkala Vidanelage